abstract：:Although significant advances in the treatment of breast cancer have been made, in particular in the use of endocrine therapy, de novo and aquired resistance to therapy, and metastatic recurrence continue to be major clinical problems. Given the high prevalence of breast cancer, new life-style or chemotherapeutic appr...

journal_title：Molecular and cellular endocrinology

authors： Nelson ER

更新日期：2018-05-05 00:00:00

abstract：:Men have had a substantially higher risk of developing bladder cancer than women. This has prompted research on androgen-mediated androgen receptor (AR) signaling in urothelial cancer. Indeed, increasing preclinical evidence indicates that AR activation correlates with the promotion of urothelial carcinogenesis and tu...

journal_title：Molecular and cellular endocrinology

authors： Inoue S,Mizushima T,Miyamoto H

更新日期：2018-04-15 00:00:00

abstract：:It has been well established for decades that androgens, namely testosterone (T) plays an important role in female reproductive physiology as the precursor for oestradiol (E2). However, in the last decade a direct role for androgens, acting via the androgen receptor (AR), in female reproductive function has been confi...

journal_title：Molecular and cellular endocrinology

authors： Walters KA,Handelsman DJ

更新日期：2018-04-15 00:00:00

abstract：:The anterior pituitary gland is a key organ involved in the control of multiple physiological functions including growth, reproduction, metabolism and stress. These functions are controlled by five distinct hormone-producing pituitary cell types that produce growth hormone (somatotropes), prolactin (lactotropes), adre...

journal_title：Molecular and cellular endocrinology

authors： Vázquez-Borrego MC,Gahete MD,Martínez-Fuentes AJ,Fuentes-Fayos AC,Castaño JP,Kineman RD,Luque RM

更新日期：2018-03-05 00:00:00

abstract：:The functions of anterior pituitary cells are controlled by two major groups of hypothalamic and intrapituitary ligands: one exclusively acts on G protein-coupled receptors and the other activates both G protein-coupled receptors and ligand-gated receptor channels. The second group of ligands operates as neurotransmit...

journal_title：Molecular and cellular endocrinology

authors： Zemková H,Stojilkovic SS

更新日期：2018-03-05 00:00:00

abstract：:The role of protein kinase C (PKC) isoforms (PKCs) in GnRH-stimulated MAPK [ERK1/2, JNK1/2 and p38) phosphorylation was examined in gonadotrope derived cells. GnRH induced a protracted activation of ERK1/2 and a slower and more transient activation of JNK1/2 and p38MAPK. Gonadotropes express conventional PKCα and PKCβ...

journal_title：Molecular and cellular endocrinology

authors： Mugami S,Dobkin-Bekman M,Rahamim-Ben Navi L,Naor Z

更新日期：2018-03-05 00:00:00

abstract：CONTEXT:Apart from 21 Hydroxylase deficiency, other subtypes of congenital adrenal hyperplasia (CAH) are rare. We studied the clinical features and molecular genetics of a relatively large series of patients with CYP17A1, HSD3β2 and StAR deficiencies. PATIENTS AND METHODS:We studied 21 patients including 7 patients wi...

journal_title：Molecular and cellular endocrinology

authors： Alswailem MM,Alzahrani OS,Alhomaidah DS,Alasmari R,Qasem E,Murugan AK,Alsagheir A,Brema I,Abbas BB,Almehthel M,Almeqbali A,Alzahrani AS

更新日期：2018-02-05 00:00:00

abstract：OBJECTIVE:Significant attempts are being made to generate multifunctional, hybrid or peptide combinations as novel therapeutic strategies for type 2 diabetes, however this presents key challenges including design and pharmaceutical development. In this study, we evaluated metabolic properties of oral nutritional supple...

journal_title：Molecular and cellular endocrinology

authors： Pathak NM,Millar PJB,Pathak V,Flatt PR,Gault VA

更新日期：2018-01-15 00:00:00

abstract：:Advanced glycation end products (AGEs), formed at an accelerated rate under diabetes, play a role in inflammation and fibrosis in mesangial areas in diabetic nephropathy (DN). However, the transcriptional modulator that mediates the cellular response to AGEs remains largely obscure. Our goal was to determine whether m...

journal_title：Molecular and cellular endocrinology

authors： Chen Q,Huang J,Gong W,Chen Z,Huang J,Liu P,Huang H

更新日期：2018-01-15 00:00:00

abstract：:Vaspin expression is increased in white adipose tissue (WAT) of diet-induced obese mice and rats and is supposed to compensate HFD-induced inflammatory processes and insulin resistance in adipose tissue by counteracting pro-inflammatory gene expression in obesity. Multiple studies have also demonstrated strong anti-in...

journal_title：Molecular and cellular endocrinology

authors： Zieger K,Weiner J,Krause K,Schwarz M,Kohn M,Stumvoll M,Blüher M,Heiker JT

更新日期：2018-01-15 00:00:00

abstract：:Hypothalamic dysfunction is a common feature of experimental obesity. Studies have identified at least three mechanisms involved in the development of hypothalamic neuronal defects in diet-induced obesity: i, inflammation; ii, endoplasmic reticulum stress; and iii, mitochondrial abnormalities. However, which of these ...

journal_title：Molecular and cellular endocrinology

authors： Carraro RS,Souza GF,Solon C,Razolli DS,Chausse B,Barbizan R,Victorio SC,Velloso LA

更新日期：2018-01-15 00:00:00

abstract：:The decidualization process involves phenotype and functional changes on endometrial cells and the modulation of mediators with immunoregulatory properties as the vasoactive intestinal peptide (VIP). We investigate VIP contribution to the decidualization program and to immunoregulation throughout the human embryo impl...

journal_title：Molecular and cellular endocrinology

authors： Grasso E,Gori S,Paparini D,Soczewski E,Fernández L,Gallino L,Salamone G,Martinez G,Irigoyen M,Ruhlmann C,Pérez Leirós C,Ramhorst R

更新日期：2018-01-15 00:00:00

abstract：:This short review aims to assess the application of basic quality assurance (QA) principles in published thyroid hormone bioanalytical methods using mass spectrometry (MS). The use of tandem MS, in particular linked to liquid chromatography has become an essential bioanalytical tool for the thyroid hormone research co...

journal_title：Molecular and cellular endocrinology

authors： Richards K,Rijntjes E,Rathmann D,Köhrle J

更新日期：2017-12-15 00:00:00

abstract：:The growing burden of obesity- and aging-related diseases has hastened the search for governing biological processes. Cellular senescence is a stress-induced state of stable growth arrest strongly associated with aging that is aberrantly activated by obesity. The transition of a cell to a senescent state is demarcated...

journal_title：Molecular and cellular endocrinology

authors： Schafer MJ,Miller JD,LeBrasseur NK

更新日期：2017-11-05 00:00:00

abstract：:Globally, the aging population is growing rapidly, creating an urgent need to attenuate age-related health conditions, including metabolic disease and disability. A promising strategy for healthy aging based on consistently positive results from studies with a variety of species, including non-human primates (NHP), is...

journal_title：Molecular and cellular endocrinology

authors： Das SK,Balasubramanian P,Weerasekara YK

更新日期：2017-11-05 00:00:00

abstract：:All organisms need to be capable of adapting to changes in the availability and composition of nutrients. Over 75 years ago, researchers discovered that a calorie restricted (CR) diet could significantly extend the lifespan of rats, and since then a CR diet has been shown to increase lifespan and healthspan in model o...

journal_title：Molecular and cellular endocrinology

authors： Cummings NE,Lamming DW

更新日期：2017-11-05 00:00:00

abstract：INTRODUCTION:Iron overload leads to multiple organ damage including endocrine organ dysfunctions. Hypogonadism is the most common non-diabetic endocrinopathy in primary and secondary iron overload syndromes. AIM:To explore the molecular determinants of iron overload-induced hypogonadism with specific focus on hypothal...

journal_title：Molecular and cellular endocrinology

authors： Macchi C,Steffani L,Oleari R,Lettieri A,Valenti L,Dongiovanni P,Romero-Ruiz A,Tena-Sempere M,Cariboni A,Magni P,Ruscica M

更新日期：2017-10-15 00:00:00

abstract：:Fsh-mediated regulation of zebrafish spermatogenesis includes modulating the expression of testicular growth factors. Here, we study if and how two Sertoli cell-derived Fsh-responsive growth factors, anti-Müllerian hormone (Amh; inhibiting steroidogenesis and germ cell differentiation) and insulin-like growth factor 3...

journal_title：Molecular and cellular endocrinology

authors： Morais RDVS,Crespo D,Nóbrega RH,Lemos MS,van de Kant HJG,de França LR,Male R,Bogerd J,Schulz RW

更新日期：2017-10-15 00:00:00

abstract：:The skin represents a pivotal organ for the human body's vitamin D endocrine system, being both the site of ultraviolet (UV)-B-induced vitamin D synthesis and a target tissue for the pluripotent effects of 1,25(OH)2D3 and other biologically active vitamin D metabolites. As many other steroid hormones, 1,25(OH)2D3 exer...

journal_title：Molecular and cellular endocrinology

authors： Reichrath J,Saternus R,Vogt T

更新日期：2017-09-15 00:00:00

abstract：:1,25(OH)2D3 (vitamin D) is well-recognized as a neurosteroid that modulates multiple brain functions. A growing body of evidence indicates that vitamin D plays a pivotal role in brain development, neurotransmission, neuroprotection and immunomodulation. However, the precise molecular mechanisms by which vitamin D exer...

journal_title：Molecular and cellular endocrinology

authors： Cui X,Gooch H,Petty A,McGrath JJ,Eyles D

更新日期：2017-09-15 00:00:00

abstract：:In ruminants, prostaglandin F2alpha (PGF2α)-mediated luteolysis is essential prior to estrous cycle resumption, and is a target for improving fertility. To deduce early PGF2α-provoked changes in the corpus luteum a short time-course (0.5-4 h) was performed on cows at midcycle. A microarray-determined transcriptome was...

journal_title：Molecular and cellular endocrinology

authors： Talbott H,Hou X,Qiu F,Zhang P,Guda C,Yu F,Cushman RA,Wood JR,Wang C,Cupp AS,Davis JS

更新日期：2017-09-05 00:00:00

abstract：:Obesity may cause several metabolic complications, including insulin resistance and type 2 diabetes mellitus. Despite great advances in medicine, people still keep exploring novel and effective drugs for treatment of obesity and insulin resistance. The aim of this study was to survey if baicalin might ameliorate obesi...

journal_title：Molecular and cellular endocrinology

authors： Fang P,Yu M,Zhang L,Wan D,Shi M,Zhu Y,Bo P,Zhang Z

更新日期：2017-06-15 00:00:00

abstract：:Glucocorticoids play a primary role in the maturation of fetal organs and may contribute to the onset of labour. Glucocorticoid activity depends on the 11β-hydroxysteroid dehydrogenase family (11β-HSDs), catalysing the interconversion between "active" cortisol into inactive cortisone. No definitive study exists on 11β...

journal_title：Molecular and cellular endocrinology

authors： Damiani F,Makieva S,Rinaldi SF,Hua L,Marcolongo P,Petraglia F,Norman JE

更新日期：2017-05-15 00:00:00

abstract：:It is well known that ovulation is induced by luteinizing hormone (LH) surge. However, the down-stream factors that mediating LH surge induced ovulation are less clear. The cyclooxygenases (also known as PTGS) as key enzymes for prostaglandins synthesis appear to be important for ovulation in mammals, but their functi...

journal_title：Molecular and cellular endocrinology

authors： Tang H,Liu Y,Li J,Li G,Chen Y,Yin Y,Guo Y,Cheng CH,Liu X,Lin H

更新日期：2017-05-15 00:00:00

abstract：:The endocrine function of the ovary is dependent upon the ovarian follicle, which on a cellular basis consists of an oocyte surrounded by adjacent somatic cells responsible for generating sex steroid hormones and maintenance of hormonal stasis with the hypothalamic-pituitary axis. As females age, both fertility and th...

journal_title：Molecular and cellular endocrinology

authors： Truman AM,Tilly JL,Woods DC

更新日期：2017-04-15 00:00:00

abstract：CONTEXT:Hyperandrogenic states and obesity in women are associated with insulin-resistance. Androgens reduce glucose uptake in adipose cells and increase TNFα production in peripheral monocytes. Inflammatory cytokines have a known detrimental effect on insulin resistance. The aim of the present study was to explore the...

journal_title：Molecular and cellular endocrinology

authors： Crisosto N,Flores C,Maliqueo M,Echiburú B,Vásquez J,Maluenda F,Sir-Petermann T

更新日期：2017-03-15 00:00:00

abstract：:Since occupational exposure to acrylamide (ACR) may cause nerve damage, sensitive biomarkers to evaluate the early effects of ACR on human health are needed. In the present study, we have compared a group of individuals with occupational exposure to ACR (contact group, n = 65) with a group of individuals with no expos...

journal_title：Molecular and cellular endocrinology

authors： Wang SY,Yu CP,Pan YL,Zhou XR,Xin R,Wang Y,Ma WW,Gao R,Wang C,Wu YH

更新日期：2017-03-15 00:00:00

abstract：:Trophoblast cells produce several inmmuneregulators like the Vasoactive Intestinal Peptide (VIP) and P4 targeting multiple circuits, and also display an intese phagocytic ability allowing embryo implantation in a tolerogenic context. Here, we explored whether P4 and VIP- crosstalk modulates trophoblast cell function, ...

journal_title：Molecular and cellular endocrinology

authors： Vota D,Aguero M,Grasso E,Hauk V,Gallino L,Soczewski E,Pérez Leirós C,Ramhorst R

更新日期：2017-03-05 00:00:00

abstract：:Recent findings demonstrated that a subset of papillary thyroid cancers (PTCs) is characterized by reduced expression of the von Hippel-Lindau (VHL) tumor suppressor gene, and that lowest levels associated with more aggressive PTCs. In the present study, the levels of the two VHL mRNA splicing variants, VHL-213 (V1) a...

journal_title：Molecular and cellular endocrinology

authors： Baldini E,Tuccilli C,Arlot-Bonnemains Y,Chesnel F,Sorrenti S,De Vito C,Catania A,D'Armiento E,Antonelli A,Fallahi P,Watutantrige-Fernando S,Tartaglia F,Barollo S,Mian C,Bononi M,Arceri S,Mascagni D,Vergine M,Pironi D

更新日期：2017-03-05 00:00:00

abstract：:Foods and botanical supplements can interfere with the endocrine system through the presence of phytosteroids - chemicals that interact with steroids receptors. Phytoestrogens are well studied, but compounds such as kaempferol, apigenin, genistein, ginsenoside Rf, and glycyrrhetinic acid have been shown to interact wi...

journal_title：Molecular and cellular endocrinology

authors： Dean M,Murphy BT,Burdette JE

更新日期：2017-02-15 00:00:00

abstract：:We have previously reported that LHCGR expression in the ovary is regulated through a post-transcriptional mechanism involving an mRNA binding protein designated as LRBP, which is regulated, at least in part, by a non-coding RNA, miR-122. Our present study examined the regulatory role of miR-122 in FSH-induced LHCGR e...

journal_title：Molecular and cellular endocrinology

authors： Menon B,Gulappa T,Menon KM

更新日期：2017-02-15 00:00:00

abstract：:Steroids are synthesized from the adrenal glands and gonads by enzymes of the cytochromes P450 and hydroxysteroid dehydrogenase in nature. These enzymes are located in the membrane of endoplasmic reticulum and mitochondria to catalyze redox reactions using electrons transported from the membrane. In the mitochondria, ...

journal_title：Molecular and cellular endocrinology

authors： Chien Y,Rosal K,Chung BC

更新日期：2017-02-05 00:00:00

abstract：:Steroidogenesis refers to the de novo synthesis of steroid hormones from cholesterol by a number of sequential enzyme catalysed reactions in the adrenal and the gonads. In addition, circulating steroid hormone precursors are further metabolised in selected peripheral tissues. It has been suggested that the biosynthesi...

journal_title：Molecular and cellular endocrinology

authors： Louw-du Toit R,Storbeck KH,Cartwright M,Cabral A,Africander D

更新日期：2017-02-05 00:00:00

abstract：:We hypothesized that DNA methylation is involved in human adrenal functional zonation. mRNAs expression and methylation pattern of RARB, NR4A1 and HSD3B2 genes in human adrenal tissues (HAT) and in pediatric virilizing adrenocortical tumors (VAT) were analyzed. For analysis of the results samples were divided into 3 a...

journal_title：Molecular and cellular endocrinology

authors： Baquedano MS,Perez Garrido N,Goñi J,Saraco N,Aliberti P,Berensztein E,Rivarola MA,Belgorosky A

更新日期：2017-02-05 00:00:00

abstract：:The Steroidogenic acute regulatory protein (StAR) directs mitochondrial cholesterol uptake through a C-terminal cholesterol binding domain (CBD) and a 62 amino acid N-terminal regulatory domain (NTD) that contains an import sequence and conserved sites for inner membrane metalloproteases. Deletion of the NTD prevents ...

journal_title：Molecular and cellular endocrinology

authors： Lee J,Yamazaki T,Dong H,Jefcoate C

更新日期：2017-02-05 00:00:00

abstract：:People with Type 2 diabetes mellitus (T2DM) have reduced bone mineral density and an increased risk of fractures due to altered mesenchymal stem cell (MSC) differentiation in the bone marrow. This leads to a shift in the balance of differentiation away from bone formation (osteogenesis) in favour of fat cell developme...

journal_title：Molecular and cellular endocrinology

authors： Chen SC,Brooks R,Houskeeper J,Bremner SK,Dunlop J,Viollet B,Logan PJ,Salt IP,Ahmed SF,Yarwood SJ

更新日期：2017-01-15 00:00:00

abstract：:Proinsulin folding imperfections cause extensive beta-cell defects known in diabetes. Here, we investigated whether exenatide can alleviate such defects in proinsulin conversion, beta-cell survival, and insulin secretion, in the Ins2+/Akita beta-cells that have a spontaneous mutation (Cys 96 Tyr) in the insulin 2 gene...

journal_title：Molecular and cellular endocrinology

authors： Tang W,Yuan Q,Xu B,Osei K,Wang J

更新日期：2017-01-05 00:00:00

abstract：:17beta-hydroxysteroid dehydrogenase type 1 (17β-HSD1) is a steroidal enzyme which, in breast cancer cells, mainly synthesizes 17-beta-estradiol (E2), an estrogenic hormone that stimulates breast cancer cell growth. We previously showed that the enzyme increased breast cancer cell proliferation via a dual effect on E2 ...

journal_title：Molecular and cellular endocrinology

authors： Aka JA,Calvo EL,Lin SX

更新日期：2017-01-05 00:00:00

abstract：:Skeletal muscle atrophy is a debilitating response to several major diseases, muscle disuse and chronic steroid treatment for which currently no therapy is available. Since adiponectin signaling plays key roles in muscle energetics, we assessed if globular adiponectin (gAd) or the small molecule adiponectin mimetic 6-...

journal_title：Molecular and cellular endocrinology

authors： Singh AK,Shree S,Chattopadhyay S,Kumar S,Gurjar A,Kushwaha S,Kumar H,Trivedi AK,Chattopadhyay N,Maurya R,Ramachandran R,Sanyal S

更新日期：2017-01-05 00:00:00

abstract：:Lipid storage and adipokine secretion are critical features of adipocytes. Annexin A6 (AnxA6) is a lipid-binding protein regulating secretory pathways and its role in adiponectin release was examined. The siRNA-mediated AnxA6 knock-down in 3T3-L1 preadipocytes impaired proliferation, and differentiation of AnxA6-deple...

journal_title：Molecular and cellular endocrinology

authors： Krautbauer S,Haberl EM,Eisinger K,Pohl R,Rein-Fischboeck L,Rentero C,Alvarez-Guaita A,Enrich C,Grewal T,Buechler C,Neumeier M

更新日期：2017-01-05 00:00:00